Compositions for reprogramming a cell and uses therefor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) C07K 14/035 (2006.01) C07K 14/47 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2658180

The present invention generally provides therapeutic compositions and methods for treating a disease, disorder, or injury characterized by a deficiency in the number or biological activity of a cell of interest. The method provides compositions for generating reprogrammed cells or for increasing regeneration in a cell, tissue, or organ of interest. Such methods are useful for treating subjects having a deficiency in a particular cell type or in a polypeptide produced by that cell type. In particular, the invention provides prophylactic and therapeutic methods and compositions for ameliorating or preventing hyperglycemia associated with type 1 and type II diabetes and related complications.

La présente invention concerne de manière générale des compositions et des procédés de traitement d'une maladie, d'un trouble ou d'une blessure caractérisée par une déficience dans le nombre ou l'activité biologique d'une cellule d'intérêt. Le procédé fournit des compositions pour générer des cellules reprogrammées ou pour accroître la régénération dans une cellule, un tissu ou un organe d'intérêt. De tels procédés sont utiles pour le traitement de sujets présentant une déficience en un type particulier de cellule ou en un polypeptide produit par ce type de cellule. L'invention concerne notamment des procédés prophylactiques et thérapeutiques et des compositions pour l'amélioration ou la prévention de l'hyperglycémie associée au diabète de type I et de type II et des complications associées.

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