Compositions for site-specific delivery of imatinib and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/506 (2006.01) A61K 9/14 (2006.01) A61K 9/30 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2715422

The invention provides an oral formulation for administering to a subject comprising an imatinib compound and an enteric matrix or enteric coating or a combination thereof, whereby at least 80% of the imatinib compound is released in the small intestine of the subject. Methods of using such formulation is also provided.

La présente invention concerne une formulation orale destinée à être administrée à un sujet qui comprend un composé dimatinib et une matrice gastrorésistante ou un enrobage gastrorésistant ou une combinaison de ceux-ci, moyennant laquelle au moins 80 % du composé dimatinib sont libérés dans lintestin grêle du sujet. L'invention concerne également des procédés d'utilisation de ces formulations.

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