A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 47/30 (2006.01)
Patent
CA 2430481
A composition for the sustained delivery of a drug comprising an amphiphilic diblock copolymer; a poorly water-soluble drug; a biodegradable polymer; and liquid poly(ethylene glycol) or functional derivatives thereof and a process for preparing the composition are disclosed. When administered into a particular body site, the composition forms an implant and the drug and polymeric micelles containing the same are slowly released from the implant to maintain a constant drug concentration for an extended period of time.
La présente invention concerne, d'une part une composition permettant la libération prolongée d'un médicament comprenant un copolymère dibloc amphiphile, d'autre part un médicament difficilement hydrosoluble. L'invention concerne également un polymère biodégradable, un polyéthylèneglycol-éthylèneglycol liquide ou l'un de ses dérivés fonctionnels, et un procédé permettant d'élaborer la composition. Une fois administrée en un site anatomique défini, la composition se constitue en implant, ce qui fait que le médicament et les micelles polymères le contenant se libèrent lentement de l'implant, de façon à entretenir une concentration constante du médicament sur une durée prolongée.
Kim Jae-Hong
Lee Sang-Jun
Seo Min-Hyo
Yi Yil-Woong
Robic
Samyang Corporation
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