C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2216717
The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast, gastrointestinal, lung tumors, and neoplastic conditions such as leukemias and lymphomas. Genes are identified that are differentially expressed in benign (e.g., non-malignant) tumor cells relative to malignant tumor cells exhibiting a high metastatic potential. Genes are also identified via the ability of their gene products involved in the progression to, and/or aggressiveness of, neoplastic tumor disease states.
L'invention concerne des méthodes et des compositions pour le diagnostic, la prévention et le traitement de la progression des cellules responsables de tumeurs humaines, telles que les mélanomes, les cancers du sein de l'appareil digestif et du poumon et les affections néoplasiques comme les leucémies et les lymphomes. D'après leurs gènes, les cellules sont classées soit en cellules tumorales bénignes (c'est-à-dire non malignes) soit en cellules tumorales malignes à fort potentiel métastasique. Les gènes sont aussi classés en fonction de la capacité de leur produit génique à faire progresser ou à aggraver les affections tumorales néoplasiques.
Blake Cassels & Graydon Llp
Millenium Pharmaceuticals Inc.
LandOfFree
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