Compositions for the inhibition of bone resorption

Details Compositions for the inhibition of bone resorption Compositions for the inhibition of bone resorption

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/451 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2280722

The disclosed invention is based on the observation that functional NMDA receptors are present on osteoclasts. Use of NMDA antagonists to inhibit bone resorption is disclosed, useful therefore in the treatment of bone disorders such as osteoporosis and Paget's disease. The NMDA antagonists used were Phencyclidine and Dizocilpine.

La présente invention se base sur l'observation selon laquelle les récepteurs NMDA fonctionnels sont présents sur les ostéoclastes. Cette invention concerne l'utilisation d'antagonistes NMDA pour inhiber la résorption osseuse, ces antagonistes étant utiles au traitement de maladies osseuses, telles que l'ostéoporose et la maladie de Paget. Les antagonistes NMDA utilisés étaient la phencyclidine et la dizocilpine.

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