Compositions for the inhibition of protein hormone formation...

Details Compositions for the inhibition of protein hormone formation... Compositions for the inhibition of protein hormone formation...

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) A61K 38/06 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 5/087 (2006.01) C07K 14/525 (2006.01) C07K 14/81 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12P 21/08 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2139127

Compounds having proteolytic inhibitory activity useful for treating diseases, particularly as applied to the treatment of sepsis, AIDS or autoimmune diseases, resulting from a decrease in the circulating level of mature protein hormones derived from the proteolytic cleavage of prohormone precursors such as 26 kD TNF, and methods for identifying compounds having the de- sired inhibitory activity are provided.

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