Compositions for the inhibition of tnf formation and uses...

Details Compositions for the inhibition of tnf formation and uses... Compositions for the inhibition of tnf formation and uses...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/06 (2006.01) A61K 39/395 (2006.01) C07K 5/06 (2006.01) C07K 14/525 (2006.01) C07K 14/81 (2006.01) C07K 16/40 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2185162

Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is useful for discovering inhibitors of excessive release of mature active TNF.alpha.. Also disclosed are methods for the identification of inhibitors of the conversion of the pro-form of TNF.alpha. to its mature active form.

On décrit ici des méthodes et l'équipement utilisés pour la préparation de protéase neutrophile active humaine de recombinaison purifiée, PR-3, obtenue par activation d'une pro-forme appelée ici pro-PR-3. La PR-3 humaine est utile pour découvrir les inhibiteurs empêchant une libération excessive du facteur TNF alpha mature et actif. On décrit également des méthodes d'identification des inhibiteurs de la conversion de la pro-forme du TNF alpha en forme mature et active.

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