Compositions for the preparation of mature dendritic cells

Details Compositions for the preparation of mature dendritic cells Compositions for the preparation of mature dendritic cells

C - Chemistry, Metallurgy

12

N

C12N 5/06 (2006.01)

Patent

CA 2647622

The invention relates to a method for in vitro maturation of at least one immature dendritic cell, comprising stimulating said immature dendritic cell with TNF.alpha., IL- l.beta., IFN.gamma., a TLR7/8 agonist and prostaglandin E2 (PG). Furthermore, the invention relates to a composition comprising said factors as well as to mature dendritic cells produced by the method of the invention.

L'invention concerne un procédé de maturation in vitro d'au moins une cellule dendritique immature, comprenant la stimulation de ladite cellule dendritique immature avec du TNF.alpha., de l'IL-1.beta., de l'IFN.gamma., un agoniste de TLR7/8 et de la prostaglandine E2 (PG). En outre, l'invention concerne une composition comprenant ces facteurs, ainsi que des cellules dendritiques matures produites par le procédé de l'invention.

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