A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/715 (2006.01) A61K 31/725 (1990.01)
Patent
CA 2102207
2102207 9219249 PCTABS00017 The present invention relates to pharmaceutical compositions for the prevention and/or treatment of pathological processes involving the induction of TNF-.alpha. secretion comprising a pharmaceutically acceptable carrier and a low molecular weight heparin (LMWH). In the pharmaceutical compositions of the present invention, the LMWH is present in a low effective dose and is administered at intervals of about 5-8 days. Furthermore, the LMWH is capable of inhibiting in vitro TNF-.alpha. secretion by resting T cells and/or macrophages in response to T cell-specific antigens, mitogens, macrophage activators, disrupted extracellular matrix (dECM), laminin, fibronectin, and the like.
Cohen Irun R.
Hershkoviz Rami
Lider Ofer
Ltd. Yeda Research And Development Co.
Osler Hoskin & Harcourt Llp
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