A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7028 (2006.01) A61K 31/575 (2006.01) A61K 47/48 (2006.01) C07J 63/00 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2616589
Avicins and other thioesterification agents are used to modify cysteine groups of signaling proteins in order to modify their activity. Pathologies associated with signaling proteins which are regulatable through this method are treated using these thioesterification agents. These pathologies include those involving proteins which modulate physiologic redox status of organisms including arthersclerosis, cancer, bacterial infection, inflammation, and neurological disorders.
On utilise des avicines et d'autres agents de thioesterification pour modifier des groupes cystéine de protéines de signalisation afin de modifier leur activité. Des pathologies associées aux protéines de signalisation qui peuvent être régulée par cette technique sont traitées au moyen de ces agents de thioesterification. Ces pathologies comprennent celles dans lesquelles entrent en jeu des protéines qui modulent l'état redox physiologique d'organismes, notamment l'artériosclérose, le cancer, l'infection bactérienne, l'inflammation et les troubles neurologiques.
Gutterman Jordan
Stamler Jonathan S.
Duke University
Research Development Foundation
Ridout & Maybee Llp
LandOfFree
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