Compositions for the transport of therapeutic molecules into...

A - Human Necessities – 61 – K

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Details

A61K 47/48 (2006.01) A61K 31/70 (2006.01) A61K 47/42 (2006.01) A61P 11/00 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2488879

The invention relates to a composition comprising at least one therapeutic molecule for the treatment of lung cancers or pulmonary diseases and at least one peptide vector which may augment the bioavailibility of said molecule within the lungs, selected from the group Ala-Trp-Ser-Phe-Arg-Val-Ser-Tyr-Arg-Gly-Ile-Ser-Tyr-Arg-Arg-Ser-Arg (SynB4) and Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Cit-Cit-Cit-Phe-Ser-Thr-Ser-Thr-Gly-Arg (SynB6). The invention further relates to pharmaceutical compositions comprising said compounds, useful for the treatment of lung cancers or pulmonary diseases.

La présente invention a pour objet un composé constitué d~au moins une molécule thérapeutique destinée au traitement des cancers du poumon ou de maladies pulmonaires et d~au moins un peptide vecteur capable d~augmenter la biodisponibilité de ladite molécule au niveau des poumons choisi dans le groupe constitué par Ala-Trp-Ser-Phe-Arg-Val-Ser-Tyr-Arg-Gly-Ile-Ser-Tyr-Arg- Arg-Ser-Arg (SynB4) et Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Cit-Cit-Cit-Phe-Ser-Thr- Ser-Thr-Gly-Arg (SynB6). L~invention concerne aussi les compositions pharmaceutiques contenant ces composés, utiles pour le traitement des cancers du poumon ou des maladies pulmonaires.

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