Compositions for the treatment and prevention of pain and...

A - Human Necessities – 61 – K

Patent

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A61K 31/737 (2006.01) A61K 31/202 (2006.01) A61K 31/366 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61K 31/7008 (2006.01) A61K 31/726 (2006.01) A61K 45/00 (2006.01) A61P 1/02 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 5/14 (2006.01) A61P 7/06 (2006.01) A61P 7/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/

Patent

CA 2457452

A method of treating, preventing, or inhibiting pain, inflammation or inflammation-associated disorder in a subject in need of such treatment or prevention provides for treating the subject with chondroitin sulfate and a cyclooxygenase-2 selective inhibitor, or a prodrug thereof, wherein the amount of chondroiting sulfate and the amount of a cyclooxygenase-2 selective inhibitor or a pharmaceutically acceptabla salt or prodrug thereof together constitute a pain ir inflammation suppressing treatment or prevention effective amount. Glucosamine can optionally be present. Compositions that contain the combination of chondroitin sulfate and cyclooxygenase-2 selective inhibitor and, optionally, the glucosamine, are disclosed, as are pharmaceutical compositions.

L'invention se rapporte à une méthode de traitement, de prévention ou d'inhibition de la douleur, de l'inflammation ou d'un trouble associé à l'inflammation chez un patient nécessitant un tel traitement ou une telle prévention consistant à traiter le patient avec un sulfate de chondroïtine et un inhibiteur sélectif de cyclooxygénase-2, ou avec son promédicament, la quantité de sulfate de chondroïtine et la quantité d'un inhibiteur sélectif de cyclooxygénase-2 ou d'un sel pharmaceutiquement acceptable ou encore de leur promédicament s'avérant efficace dans le traitement ou la prévention d'une douleur ou d'une inflammation. On peut éventuellement ajouter de la glucosamine. Font également l'objet de cette invention des compositions contenant une combinaison de sulfate de chondroïtine et d'inhibiteur sélectif de cyclooxygénase-2 et, éventuellement, de glucosamine ainsi que des compositions pharmaceutiques.

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