Compositions for the treatment of chronic fatigue syndrome

Details Compositions for the treatment of chronic fatigue syndrome Compositions for the treatment of chronic fatigue syndrome

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 38/17 (2006.01) C07K 14/73 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2102606

The present invention relates to a method of treating chronic fatigue syndrome not associated with an HIV infection. In the method of the present invention patients are administered a pharmaceutically acceptable carrier together with (1) a neuropsychi- atrically effective amount of a linear peptide of formula (I): R a-Ser-Thr-Thr- Thr-Asn-Tyr-R6, wherein R a is Ala, D-Ala or Cys- Ala-, and R6 is Thr, Thr-amide, Thr-Cys or Thr-Cys-amide, or a derivative of the peptide or a physiologically acceptable salt thereof; or (2) a neuropsychiatrically effective amount of a linear peptide of formula (II): R1-R2-R3-R4-R5, wherein R1 is X- Y or Y when Y is Thr-, Ser-, Asn-, Leu-, Ile-, Arg- or Glu-, and X is Cys; R2 is Thr-, Ser- or Asp; R3 is Thr, Slr, Asn, Arg, Gln, Lys or Trp; R4 is Tyr; and R5 is Z-X or Z wherein Z is an amino acid and X is Cys, or a derivative of the peptide or a physiologically acceptable salt thereof; or (3) a neuropsychiatrically effective amount of a linear peptide of formula (III): R x-R2-R3-R4-R y, wherein R x is Ala-R1, D-Ala-R1 or X-Ala-R1 wherein X, R1, R2, R3, R4 are as defined above, and R y is Thr-, Thr-amide or Thr-Cys, or a derivative of the petide or a physiologically acceptable salt thereof.

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