Compositions for the treatment of infection and disease...

Details Compositions for the treatment of infection and disease... Compositions for the treatment of infection and disease...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/405 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) C07D 209/34 (2006.01) C07D 209/42 (2006.01) C07D 209/56 (2006.01) C07D 498/04 (2006.01) C07H 19/24 (2006.01)

Patent

CA 2092356

ABSTRACT The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by the hepatitis B virus (HBV). In particular, it has been discovered that the administration of low dosage amounts of 1-(2'-deoxy-2'-fluoro-.beta.-D- arabinofuranosyl)-5-iodouracil (FIAU) to humans chronically infected with HBV is effective to reduce drastically circulating markers associated with HBV. The present invention is also directed to methods of the preparation of pharmaceutical antiviral compositions.

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