Compositions for the treatment of neoplastic diseases

Details Compositions for the treatment of neoplastic diseases Compositions for the treatment of neoplastic diseases

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 9/48 (2006.01) A61K 31/337 (2006.01) A61K 31/426 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2696622

Pharmaceutical compositions and methods for the treatment of neoplastic disease and comprising the combination of a taxane, such as docetaxel, with a CYP3A4 inhibitor, such as ritonavir. Methods of treatment of neoplastic disease incorporating the administration of a taxane and the administration of a CYP3A4 inhibitor, either simultaneously or separately, are also included. Further, kits for carrying out the methods are included. Solid pharmaceutical taxane compositions for oral administration comprising a substantially amorphous taxane, a carrier and a surfactant are also included.

L'invention concerne des compositions pharmaceutiques et des procédés pour le traitement d'une maladie néoplasique, ces combinaisons renfermant une combinaison de taxane, du type decétaxel, et d'inhibiteur de CYP3A4, du type ritonavir. L'invention concerne également des procédés de traitement d'une maladie néplasique qui consistent à administrer un taxane et par ailleurs un inhibiteur de CYP3A4, soit simultanément soit isolément. Enfin, l'invention concerne des kits pour la mise en oeuvre des procédés décrits, et des compositions pharmaceutiques solides de taxane destinées à une administration orale qui renferment un taxane sensiblement amorphe, un vecteur et un tensioactif.

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