Compositions for topical treatment of skin diseases

Details Compositions for topical treatment of skin diseases Compositions for topical treatment of skin diseases

A - Human Necessities

61

K

167/244, 167/248

A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/365 (2006.01)

Patent

CA 2002715

RAN 4051/20 Abstract Compounds of formula I and II Image I II wherein R1 is hydrogen and R2 is hydroxy or R1 is methyl and R2 is hydrogen; A is alkyl; cycloalkyl; alkenyl; alkyl substituted with yrifluoromethyl; phenyl; halophenyl; phenyl-C1-3 alkyl phenyl-C1-3 alkyl substituted on the phenyl with 1 to 3 substituents selected from the group consisting of halo, C1-3 alkyl, or C1-3 alkoxy; or A is R3O(CH2)n-C-(CH3)(R4)- wherein R3 is hydrogen or (C1-5 alkyl)C-(O)-, R4 is hydrogen or methyl, and n is 1 to 5; or a pharmaceutically acceptable salt, C1-4 alkyl ester, acetylamino-C1-4 alkyl ester, phenyl-C1-4-alkyl ester, dimethylamino-C1-4-alkyl ester, or a .alpha.-monoglyceride of a compound of formula II are useful in the treatment of hyperproliferative diseases, suh as psoriasis.

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