A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/252
A61K 31/215 (2006.01) A61K 31/235 (2006.01)
Patent
CA 1188224
COMPOSITIONS FOR TREATING GLAUCOMA Abstract of the Disclosure A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula Image wherein R may be lower alkyl, lower alkynyl, aryl, or aralkyl; A may be a direct bond, lower alkylenyl, or lower alkenyl; x may be an integer from 1 to 3; Ar may be substituted or unsubstituted aromatic; R1 may be lower alkyl, lower hydroxy alkyl, lower alkenyl, lower alkynyl, or aralkyl; and pharmaceutically accepted salts thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a rela- tively short duration of action in the systemic circula- tion, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic side effects.
405136
American Hospital Supply Corporation
Osler Hoskin & Harcourt Llp
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