Compositions for treating glaucoma

Details Compositions for treating glaucoma Compositions for treating glaucoma

A - Human Necessities

61

K

167/207, 167/254

A61K 31/235 (2006.01) A61K 31/33 (2006.01)

Patent

CA 1220716

1164-130A COMPOSITIONS FOR TREATING GLAUCOMA Abstract of the Disclosure A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula Image wherein R may be lower alkyl, lower hydroxyalkyl, lower alkynyl, aralkyl, or an ester-containing group and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.

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