C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/474, 260/472
C07C 219/14 (2006.01) A61K 31/235 (2006.01)
Patent
CA 1272733
ABSTRACT A compound of the formula: Image or a pharmaceutically acceptable salt thereof; wherein R is lower hydroxyalkyl or lower alkynyl, and Ar is unsubstituted phenyl or phenyl substituted with lower alkyl of from 1 to about 5 carbon atoms, fluoro, chloro, nitro, hydroxy, amino, acyloxy, wherein the acyl portion is alkanoyl of from 2 to about 5 carbon atoms, or unsubstituted benzoyl or benzoyl sub- stituted with halogen, lower alkoxy, lower alkyl, hydroxy or a group of the formula: Image wherein R1 is lower alkyl of from 1 to about 5 carbon atoms, and n is an integer from 0 to about 5; with the proviso that when Ar is phenyl substituted with 2 or 3 hydroxy groups, or phenyl substituted with acyloxy, wherein the acyl portion is alkanoyl of from 2 to about 5 carbon atoms, or benzoyl (op- tionally substituted by halogen, alkoxy, alkyl or hydroxy), R may optionally additionally be isopropyl, t-butyl or dime- thoxyphenethyl. These compounds are useful for the treatment of glaucoma or lowering intraocular pressure in a mammal.
521655
Kam Sheung-Tsam
Matier William L.
American Hospital Supply Corporation
Kam Sheung-Tsam
Matier William L.
Osler Hoskin & Harcourt Llp
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