Compositions for treating or preventing obesity and insulin...

A - Human Necessities – 61 – K

Patent

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A61K 31/00 (2006.01)

Patent

CA 2548671

Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

L'invention concerne des méthodes et des compositions permettant de moduler l'activité ou le taux d'une sirtuine, et de traiter ou de prévenir ainsi chez un sujet l'obésité ou un trouble de résistance à l'insuline tel que le diabète. Les méthodes de traitement exemplaires comprennent la mise en contact d'une cellule avec un composé activant la sirtuine ou un composé inhibiteur, en vue d'accroître ou de réduire l'accumulation de graisse, respectivement.

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