Compositions for treating or preventing obesity and insulin...

Details Compositions for treating or preventing obesity and insulin... Compositions for treating or preventing obesity and insulin...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/05 (2006.01) A61K 31/12 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2613636

Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

L'invention concerne des procédés et des compositions permettant de moduler l'activité ou le taux d'une sirtuine, traitant ou prévenant ainsi l'obésité ou un trouble lié à la résistance à l'insuline, tel que les diabètes, chez un sujet. Dans procédés exemplaires consistent à mettre en contact une cellule avec un composé activant la sirtuine ou un composé inhibiteur afin d'accroître ou de diminuer ainsi l'accumulation de gras respectivement.

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