A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/02 (2006.01) A61K 38/16 (2006.01)
Patent
CA 2536906
The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor, pentagastrin (PG) or a PG analogue as an activator of parietal cells in the gastric lumen. In a preferred embodiment, the composition further comprises at least one agent that preserves the availability of PG in the gastric fluids, thus enabling PG to act locally in the stomach. Unexpectedly, the compositions of the present invention exhibit anti-acid activity locally in the stomach that is meal-independent, exhibit fast onset and prolonged inhibition of acid secretion.
L'invention porte sur des compositions orales innovantes comprenant un inhibiteur de la pompe à protons (IPP) agissant de manière irréversible comme antisécrétoire sur l'activité l'ATPase H+ K+ des cellules gastriques, de la pentagastrine (PG) ou un analogue de la pentagastrine comme activateur des cellules pariétales de la lumière intestinale. Dans un mode de réalisation préféré, les compositions comprennent en outre au moins un agent qui maintient la disponibilité de la pentagastrine dans les fluides gastriques, ce qui permet à la pentagastrine d'agir localement dans l'estomac. De manière inattendue, les compositions de l'invention démontrent une activité locale antiacide au niveau de l'estomac, indépendamment des repas consommés, et agissent rapidement tout en maintenant une inhibition prolongée des sécrétions d'acide.
David Ayelet
Glozman Sabina
Paul Lada
Goudreau Gage Dubuc
Vecta Ltd.
LandOfFree
Compositions for treating pathologies that necessitate... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions for treating pathologies that necessitate..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for treating pathologies that necessitate... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1445721