C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/45 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 31/14 (2006.01) A61P 31/16 (2006.01) C12N 15/44 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2586250
The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.
L'invention concerne des compositions d'ARNsi qui gênent la réplication virale des infections virales respiratoires, y compris le virus syncytial respiratoire et la grippe aviaire A, dont la souche H5N1. Cette invention porte aussi sur des utilisations des compositions d'ARNsi afin d'inhiber l'expression des gènes viraux dans cellules infectées par le virus respiratoire, ainsi que sur des utilisations associées dans le traitement d'infections dues au virus respiratoire chez un sujet. Ladite invention se rapporte à un polynucléotide contenant une première séquence nucléotidique de 15 à 30 bases ciblant le génome d'un virus syncytial respiratoire ou d'un virus de la grippe A, à un complément de celui-ci, à un polynucléotide à double brin ou un polynucléotide en épingle à cheveux. Elle concerne également des vecteurs, des cellules et des compositions pharmaceutiques contenant les séquences d'ARNsi.
Lu Patrick Y.
Tang Qingquan
Woodle Martin C.
Xie Frank Y.
Zheng Bojian
Intradigm Corporation
Smart & Biggar
LandOfFree
Compositions for treating respiratory viral infections and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions for treating respiratory viral infections and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for treating respiratory viral infections and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1833182