A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7068 (2006.01) A61K 31/05 (2006.01) A61K 31/7072 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2380924
Methods and combinations of an agent that promotes DNA synthesis in a virally- targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a subject in need thereof. Such compositions are particularly effective where the subject has resistance to a nucleoside analogue, where the subject has resting cellular reservoirs of such a virus, or to induce a post-treatment period of replication incompetence of such a virus.
L'invention concerne des procédés, et des combinaisons entre un agent favorisant la synthèse de l'ADN dans une cellule cible d'infection virale et un analogue nucléosidique ayant une activité antivirale, pour le traitement d'une infection virale chez un sujet. Ce type de composition est particulièrement efficace lorsque le sujet résiste à un analogue nucléosidique, lorsque le sujet comporte des réservoirs cellulaires repos du virus, ou lorsqu'il s'agit d'induire une période d'incompétence en réplication, postérieure au traitement, pour le virus considéré.
Davis Charles E. Jr.
Heredia Alonso
Redfield Robert R.
Kirby Eades Gale Baker
University Of Maryland Baltimore
University Of Maryland - Biotechnology Institute
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