A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/30 (2006.01) A61K 31/137 (2006.01) A61M 5/178 (2006.01) A61P 17/00 (2006.01) A61P 31/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2595620
A flowable composition suitable for forming in situ a controlled release implant system for the treatment of nail diseases, the composition comprising a pharmaceutically acceptable biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium or body fluid; a pharmaceutically acceptable biocompatible solvent that is water soluble; and a therapeutically effective amount of an active ingredient, wherein the thermoplastic polymer and biocompatible solvent are present in concentrations effective to form the implant in situ periungually or subungually. Methods, implants, uses, kits and systems are likewise provided.
La présente invention concerne une composition fluide convenant à la formation in situ d~un système d~implant à libération contrôlée pour le traitement de maladies de l~ongle, la composition comprenant un polymère thermoplastique biocompatible pharmaceutiquement acceptable qui est au moins sensiblement insoluble dans un milieu aqueux ou un corps liquide ; un solvant biocompatible pharmaceutiquement acceptable hydrosoluble ; et une quantité thérapeutiquement efficace d~un ingrédient actif, le polymère thermoplastique et le solvant biocompatible étant présents dans des concentrations efficaces pour former l~implant in situ autour de l~ongle ou sous l~ongle. L~invention concerne également des procédés, implants, utilisations, kits et systèmes.
Boch Ronald Erwin
Chan Agnes How-Ching
Curaudeau Alain H.
Lutwyche Peter
Tao Jing-Song
Qlt Inc.
Smart & Biggar
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