Compositions for treatment of inflamed tissues

Details Compositions for treatment of inflamed tissues Compositions for treatment of inflamed tissues

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/56 (2006.01) A61K 33/24 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2146565

Compositions for concentrating a therapeutic agent in an inflamed tissue region, and particularly an inflamed dermal region, are disclosed. The composition is a liposomal composition. The liposomes contain the therapeutic compound in entrapped form and are composed of vesicle-forming lipids including a vesicle-forming lipid derivatized with polyethylene glycol. After intravenous administration, the liposomes are taken up by the inflamed region within 24-48 hours, for site-specific release of and concentration of the therapeutic compound into the inflamed region.

L'invention concerne des compositions à base de liposomes permettant de concentrer un agent thérapeutique dans une région de tissus enflammés, plus particulièrement une région dermique enflammée. Les liposomes contiennent le composé thérapeutique sous forme piégée et sont composés de lipides formeurs de vésicules, y compris un lipide formeur de vésicules dérivé avec du polyéthylèneglycol. Après l'administration intraveineuse, les liposomes sont absorbés par la région enflammée dans les 24 à 48 heures afin de libérer et de concentrer le composé thérapeutique dans des sites spécifiques de la région en question.

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