Compositions for treatment of prostate and other cancers

Details Compositions for treatment of prostate and other cancers Compositions for treatment of prostate and other cancers

A - Human Necessities

61

K

A61K 31/713 (2006.01) A61K 31/7125 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2498026

The present invention makes use of therapeutic agents which target heat shock protein (hsp) 27 in vivo to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp 27. In accordance with the invention, a therapeutic agent, for example an antisense oligonucleotide or RNAi nucleotide inhibitor with sequence specificity for hsp 27 mRNA, for example human hsp 27 mRNA, is administered to an idvidivual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount. The therapeutic agent is suitably formulated into a pharmaceutical composition which includes a pharmaceutically aceptable carrier, and packaged in dosage unit form. A preferred dosage unit form is in injectable dosage unit form.

La présente invention met en oeuvre des agents thérapeutiques qui ciblent la protéine de choc thermique (hsp) 27 in vivo en vue de fournir un traitement aux individus, notamment des sujets humains, atteints du cancer de la prostate et d'autres types de cancer surexprimant la hsp 27. Selon la présente invention, un agent thérapeutique, par exemple un oligonucléotide antisens ou un inhibiteur nucléotidique d'interférence ARN à spécificité de séquence pour la hsp 17, par exemple un ARN messager de hsp 27 humain, est administré au sujet atteint du cancer de la prostate ou d'un autre type de cancer exprimant des niveaux élevés de la hsp 27 en une quantité thérapeutiquement efficace. L'agent thérapeutique présente une formulation appropriée sous la forme d'une composition pharmaceutique comprenant un support pharmaceutiquement acceptable, et conditionné sous forme d'unité posologique. Une forme d'unité posologique préférée est constituée par une forme d'unité posologique injectable.

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