Compositions for use in human therapeutics, characterised by...

Details Compositions for use in human therapeutics, characterised by... Compositions for use in human therapeutics, characterised by...

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2157758

A therapeutical composition for use in humans, comprising a combination of at least one natural or recombinant and preferably human cytokine with at least one muramyl peptide selected from those which, when administered in vivo together with an interferon, also induce an increased in vivo production of an interleukin-1 receptor antagonist IL-1 RA, but preferably do not induce any increase in TNF, IL-8 and IL-1 cytokines. Said composition is useful for antiviral and antitumoral therapies and/or for promoting restoration of the haematopoietic system, particularly in individuals with a weakened immune system.

L'invention concerne une composition associant, aux fins de leur application en thérapeutique humaine, au moins une cytokine naturelle ou recombinante, de préférence humaine, avec au moins un muramyl-peptide choisi parmi ceux qui, lorsqu'ils sont administrés in vivo en association avec un interféron, induisent également la production accrue in vivo d'un antagoniste IL-1 RA du récepteur de l'interleukine I et, de préférence, n'induisent pas un accroissement des cytokines IL-1, TNF et IL-8. Elle est utilisable pour des thérapies antivirales, antitumorales et/ou pour favoriser une reconstitution du système hématopoïétique, notamment chez des personnes dont le système immunitaire est ou a été rendu déficient.

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