Compositions having an inner core and at least two...

A - Human Necessities – 61 – K

Patent

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A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 35/74 (2006.01)

Patent

CA 2500390

The disclosure relates to compositions comprising an inner core and at least two surrounding layers. The compositions are suitable for use in humans and other mammals, particularly wherein a component of the inner core is susceptible to moisture. In particular, the disclosed compositions comprise: (a) an inner core comprising one or more components; (b) an inner layer which surrounds the inner core, wherein the inner layer is selected from the group consisting of continuous coatings insoluble at a pH of about 3 or less, continuous coatings having a coating weight of from about 3 mg / cm2 to about 25 mg / cm2, and combinations thereof; and (c) an outer layer which surrounds the inner layer, wherein the outer layer is hydrophobic.

Cette invention concerne des compositions comportant un noyau et au moins deux couches périphériques. Ces compositions peuvent s'utiliser chez l'homme et autres mammifères, en particulier lorsqu'un composant du noyau est sensible à l'humidité. Plus particulièrement, les compositions de l'invention comprennent: (a) un noyau renfermant un ou plusieurs composants; (b) une couche intérieure entourant le noyau, qui est prise dans le groupe constitué de revêtements successifs insolubles à un pH d'environ 3 ou moins, revêtements successifs dont le poids par couche varie d'environ 3 mg/cm?2¿ à environ 25 mg/cm?2¿, seuls, et en combinaison; et (c) une couche extérieure hydrophobe entourant la couche intérieure.

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