Compositions, kits and methods for administration of...

Details Compositions, kits and methods for administration of... Compositions, kits and methods for administration of...

A - Human Necessities

61

K

A61K 31/60 (2006.01) A61K 31/455 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2218696

The present invention concerns composition, kits and methods for reducing the flushing effect (cutaneous erythema) of an antilipemic drug, for treating hyperlipemia, for improving the effectiveness of an anti-platelet aggregating drug (e.g., in nonresponders) and for treating thrombosis. The present compositions and kits for reducing the flushing effect and for treating hyperlipemia contain an antilipemic drug such as niacin and either a sustained- release NSAID (such as aspirin) or an NSAID and a carboxylic acid compound other than the NSAID and antilipemic drug. The kits contain (a) predosages of the NSAID and optional carboxylic acid compound and (b) an antilipemic dosage of the antilipemic drug, which optionally may be combined with NSAID and optional carboxylic acid compound in an amount effective to maintain the reduction of the flushing effect. The present method of treating hyperlipemia comprises predosing the patient with a sustained-release NSAID or an NSAID and a carboxylic acid compound other than the NSAID and antilipemic drug at least 2 hours before administering the antilipemic drug. The present compositions and kits for increasing the effectiveness of an antiplatelet aggregating drug contain an NSAID such as aspirin, niacin or a congener thereof, and optionally, a carboxylic acid other than the NSAID niacin, such as citric acid.

L'invention porte sur des compositions, trousses et procédés tendant à réduire l'érythème cutané (bouffées congestives) dû à certains médicaments antilipémiques employés dans le traitement de l'hyperlipémie, pour améliorer l'efficacité de médicaments empêchant l'agrégation plaquettaire (par exemple chez les non-répondants) et traiter les thromboses. Lesdites compositions et trousses tendant à réduire l'érythème cutané et traitant l'hyperlipémie contiennent un antilipémique tel que la niacine et soit un NSAID (anti-inflammatoire non stéroïdien) à libération continue tel que l'aspirine, soit un NSAID et un composé d'acide carboxylique autre que le NSAID, et un antilipémique. La trousse contient: (a) un prédosage de NSAID et un composé (facultatif) de l'acide carboxylique, et (b) un dosage d'antilipémique, pouvant facultativement être combiné au NSAID, en quantité nécessaire pour réduire l'érythème cutané. Ledit procédé de traitement de l'hyperlipémie consiste à "prédoser" le patient avec un NSAID à libération continue tel que l'aspirine, ou un NSAID et un composé d'acide carboxylique autre que le NSAID et un antilipémique au moins deux heures avant l'administration de l'antilipémique. Les susdites compositions et trousses pour améliorer l'efficacité de médicaments empêchant l'agrégation plaquettaire contiennent un NSAID à libération continue tel que l'aspirine, la niacine ou leurs analogues et facultativement un acide carboxylique autre que la niacine NSAID, tel que l'acide citrique.

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