C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2361396
The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, <i>FEZ1</i>, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic, therapeutic, cell proliferation enhancement, and screening methods which involve these polynucleotides and protein. The invention further includes kits useful for performing the methods of the invention.
L'invention concerne des homologues de polynucléotides isolés avec une partie d'un brin du gène suppresseur de tumeur de l'homme, le gène <i>FEZ1</i>. L'invention traite également de la protéine suppresseur de tumeur ainsi codée, Fezl. Ces polynucléotides présentent un grand intérêt, par exemple, comme sondes, comme amorces, comme parties de vecteurs d'expression et similaires. L'invention traite également de procédés de diagnostique, de thérapie, de prolifération cellulaire et de dosage utilisant ces polynucléotides et ces protéines. L'invention a également pour objet des kits permettant de mettre en oeuvre les procédés selon l'invention.
Croce Carlo M.
Ishii Hideshi
Gowling Lafleur Henderson Llp
Thomas Jefferson University
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