C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) C07K 2/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) G01N 33/564 (2006.01) G01N 33/86 (2006.01)
Patent
CA 2491471
The present invention relates to novel methods of identifying and producing an anti-platelet autoantibody. More preferably, the invention relates to identification and production of a human monoclonal anti-platelet autoantibody. Additionally, the invention relates to methods for producing and identifying inhibitors of an anti-platelet autoantibody binding with a platelet, or a platelet component. Moreover, the invention relates to methods for treating or alleviating a disease, disorder or condition mediated by an anti-platelet autoantibody specifically binding with a platelet, or a component thereof, such as, but not limited to, idiopathic thrombocytopenic purpura, among others.
La présente invention se rapporte à de nouveaux procédés d'identification et de production d'un auto-anticorps antiplaquettaire. L'invention se rapporte de préférence à l'identification et à la production d'un auto-anticorps antiplaquettaire monoclonal humain. L'invention se rapporte en outre à des procédés de production et d'identification d'inhibiteurs d'un auto-anticorps antiplaquettaire se liant à une plaquette ou à un composant plaquettaire. L'invention se rapporte par ailleurs à des méthodes de traitement ou de soulagement d'une maladie, d'un trouble ou d'un état induit(e) par un auto-anticorps antiplaquettaire se liant spécifiquement à une plaquette ou à son composant, dont entre autres un purpura thrombocytopénique idiopathique.
Gowling Lafleur Henderson Llp
The Trustees Of The University Of Pennsylvania
LandOfFree
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