C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 19/00 (2006.01) C07K 14/47 (2006.01) C07K 14/51 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2426477
The invention relates to novel nucleic acids encoding a mammalian adventitia inducible and bone expressed gene designated REMODEL, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, negative remodeling, arterial restenosis, vessel injury, ectopic ossification, fibrosis, and the like. REMODELIN also plays a role in cell-cell and cell-matrix adhesion, bone density, bone formation, dorsal closure, one mineralization, calcification/ossification, and is associated with spina bifida-like phenotype. In addition, the invention related to affecting REMODELIN expression by administration of TGF-.szlig. and control of cellular gene expression using REMODELIN. The invention further relates to methods of treating and detecting these diseases, disorders or conditions, comprising modulating or detecting REMODELIN expression and/or production of REMODELIN.
L'invention concerne de nouveaux acides nucléiques codant un gène mammalien inductible dans l'adventice et exprimé dans les os, qui a reçu le nom de REMODEL, ainsi que des protéines pour lesquelles il code et dont l'expression est renforcée lors de certaines maladies, troubles et états, y compris mais de façon non limitative le remodelage négatif, la resténose artérielle, les blessures de vaisseaux, l'ossification ectopique, la fibrose et similaires. REMODELIN joue également un rôle dans l'adhérence cellule-cellule et cellule-matrice, la densité osseuse, la formation d'os, l'adhésion dorsale, la minéralisation osseuse, la calcification/ossification et est associée au phénotype similaire à "spina bifida". En outre, l'invention concerne l'affectation de l'expression de REMODELIN par l'administration de TGF-.szlig. et la régulation de l'expression génique cellulaire au moyen de REMODELIN. Elle concerne aussi des procédés pour traiter et détecter ces maladies, troubles ou états, y compris la modulation ou la detection de l'expression de REMODELIN et/ou de la production du polypeptide de REMODELIN.
Friesel Robert
Linder Volkhard
Gowling Lafleur Henderson Llp
Maine Medical Center Research Institute
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