Compositions, methods and systems for the discovery of...

Details Compositions, methods and systems for the discovery of... Compositions, methods and systems for the discovery of...

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C12N 9/10 (2006.01) C12N 9/16 (2006.01) C12N 15/54 (2006.01) C12P 1/00 (2006.01) C12P 21/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/02 (2006.01)

Patent

CA 2445687

Five protein families cooperate to form the warhead structure that characterizes enediyne compounds, both chromoprotein enediynes and non-chromoprotein enediynes. The protein family of the pesent divisional application is a thioesterase protein family members of which form, together with the enediyne polyketide synthase protein family of parent application CA 2,387,401, a polyketide synthase catalytic complex involved in warhead formation in enediynes. Genes encoding a member of each of the five protein families are found in all enediyne biosynthetic loci. The genes and proteins may be used in genetic engineering applications to design new enediyne compounds and in methods to identify new enediyne biosynthetic loci.

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