Compositions of a cholesterol biosynthesis inhibitor and a...

A - Human Necessities – 61 – K

Patent

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A61K 36/53 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2545204

Disclosed herein are methods of treating a condition associated with elevated cholesterol levels are provided, comprising administering to a mammal in need of such treatment a safe and effective amount of a cholesterol biosynthesis inhibitor and a soluble fiber. Further disclosed herein are kits comprising a first composition comprising a cholesterol biosynthesis inhibitor selected from the group consisting of HMG CoA reductase inhibitors, HMG CoA synthase inhibitors, and mixtures thereof; and a second composition comprising a soluble fiber. Even further described are compositions comprising a cholesterol biosynthesis inhibitor selected from the group consisting of HMG CoA reductase inhibitors, HMG CoA synthase inhibitors, and mixtures thereof; and a soluble fiber.

La présente invention concerne des techniques de traitement d'un état associé à des niveaux de cholestérol élevés, qui consistent à administrer à un mammifère nécessitant ce traitement une quantité efficace et sans danger d'un inhibiteur de biosynthèse de cholestérol et d'une fibre soluble. Cette invention concerne aussi des kits comprenant une première composition incluant un inhibiteur de biosynthèse de cholestérol sélectionné dans le groupe constitué d'inhibiteurs de HMG CoA réductase, d'inhibiteurs de HMG CoA synthase et de mélanges de ceux-ci et, une seconde composition comprenant une fibre soluble. Cette invention concerne enfin des compositions comprenant un inhibiteur de biosynthèse de cholestérol sélectionné dans le groupe constitué d'inhibiteurs de HMG CoA réductase, d'inhibiteurs de HMG CoA synthase et de mélanges de ceux-ci et, d'une fibre soluble.

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