Compositions of a cyclooxygenase-2 selective inhibitor...

Details Compositions of a cyclooxygenase-2 selective inhibitor... Compositions of a cyclooxygenase-2 selective inhibitor...

A - Human Necessities

61

K

A61K 31/54 (2006.01) A61K 31/352 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/444 (2006.01) A61K 31/50 (2006.01)

Patent

CA 2540623

Methods and compositions for the treatment of reduced blood flow to the central nervous system are provided. The method comprises administering to a subject a composition having a cyclooxygenase-2 selective inhibitor in combination with applying hypothermic conditions to the subject to provide improved neurological function in subjects with ischemic mediated central nervous system damage including stroke, traumatic brain and spinal cord injury.

La présente invention concerne des méthodes et des compositions permettant de traiter le ralentissement du débit sanguin vers le système nerveux central. La méthode décrite dans cette invention consiste à administrer, à un sujet, une composition comprenant un inhibiteur sélectif de la cyclooxygénase-2 et, conjointement, à placer ledit sujet dans un état d'hypothermie, de manière à obtenir une fonction neurologique améliorée chez des sujets présentant une lésion du système nerveux central induite par une ischémie, y compris, un accident vasculaire cérébral, un traumatisme cérébral et une lésion médullaire.

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