Compositions of aminoacyl-trna synthetase and uses thereof

Details Compositions of aminoacyl-trna synthetase and uses thereof Compositions of aminoacyl-trna synthetase and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2590429

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA~s, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA~s/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.

L'invention concerne des compositions et des procédés de production de constituants d'une construction biosynthétique protéinique comprenant des ARNt orthogonaux, des synthétases d'aminoacyl-ARNt orthogonaux, et des paires orthogonales de synthétases d'ARNt. L'invention concerne également des procédés destinés à identifier ces paires orthogonales et des procédés de production de protéines au moyen de ces paires orthogonales.

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