Compositions of and methods of using stabilized psma dimers

Details Compositions of and methods of using stabilized psma dimers Compositions of and methods of using stabilized psma dimers

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2629635

The invention includes cysteine-modified PSMA polypeptides and disulfide-bond- stabilized dimers thereof, compositions and kits containing the cysteine- modified PSMA polypeptides, including dimers thereof, as well as methods of producing and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, methods of producing antibodies to PSMA, including dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

La présente convention concerne des polypeptides PSMA modifiés par cystéine et des dimères stabilisés liés par disulfure de ceux-ci, des compositions et des kits contenant ces polypeptides PSMA modifiés par cystéine comprenant leurs dimères, ainsi que des procédés de production et d'utilisation de ces compositions. Ces procédés comprennent des procédés permettant d'éliciter ou d'améliorer une réponse immune sur des cellules exprimant PSMA, des procédés de production d'anticorps dirigés contre l'antigène PSMA, y compris l'antigène PSMA dimère, ainsi que des procédés de traitement du cancer, tel que le cancer de la prostate.

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