Compositions of and process for producing isotretinoin...

Details Compositions of and process for producing isotretinoin... Compositions of and process for producing isotretinoin...

A - Human Necessities

61

K

A61K 31/203 (2006.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2347098

A process for preparing a micronized isotretinoin composition is disclosed. The process is carried out by micronizing the isotretinoin while it is suspended in an oily vehicle. Compositions of micronized isotretinoin and unit dosage forms containing the compositions are also disclosed. Certain of these compositions are superior to known compositions with respect to food effect.

L'invention concerne un procédé permettant de préparer une composition d'isotrétinoïne micronisée, qui consiste à effectuer la micronisation de l'isotrétinoïne lorsque celle-ci est en suspension dans un excipient huileux. Elle concerne également des compositions d'isotrétinoïne micronisée et des formes galéniques unitaires contenant lesdites compositions. Certaines de ces compositions sont supérieures aux compositions connues en ce qui concerne l'influence de la prise alimentaire.

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