Compositions of ascorbic acid derivatives for treatment of...

A - Human Necessities – 61 – K

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A61K 31/375 (2006.01) A61K 8/11 (2006.01) A61K 8/14 (2006.01) A61K 8/67 (2006.01) A61K 31/70 (2006.01) A61Q 19/00 (2006.01) A61Q 19/02 (2006.01) A61Q 19/10 (2006.01) C07D 307/62 (2006.01) C07F 9/09 (2006.01) C07F 9/655 (2006.01) C07H 17/04 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2332808

Preventives/remedies for skin diseases characterized by containing as the active ingredient compounds represented by general formula (1) or salts thereof, i.e., ascorbic acid derivatives which per se show no antioxidative activity but can be converted into compounds with antioxidative activity in vivo. In said formula R1 represents a group which is bonded to the carbon atom at the 2-position of the ascorbic acid skeleton via an ether or ester bond and can be converted into a hydroxyl group in vivo; and R2 to R4 may be the same or different and each represents hydroxy or a group derived therefrom.

L'invention se rapporte à des agents préventifs/thérapeutiques agissant sur les affections cutanées, qui se caractérisent en ce qu'ils contiennent des composés de principes actifs représentés par la formule générale (1), ou des sels de tels composés, par exemple, des dérivés d'acide ascorbique qui ne présentent aucune activité anti-oxydation in vivo. Dans la formule (1), R?1¿ représente un groupe qui est lié à l'atome de carbone en position 2 du squelette de l'acide ascorbique via une liaison éther ou ester et peut être transformé en un groupe hydroxyle in vivo; et R?2¿, R?3¿ et R?4¿ peuvent être identiques ou différents et représentent chacun un hydroxy ou un groupe dérivé d'un hydroxy.

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