Compositions of asymmetric interfering rna and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/113 (2010.01) A61K 31/713 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2735166

The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5 '-overhang, 3 '-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.

La présente invention concerne des molécules d'ARN duplex asymétrique qui sont capables d'effectuer un silençage de gènes spécifique d'une séquence. La molécule d'ARN comprend un premier brin et un second brin. Le premier brin est plus long que le second. La molécule d'ARN comprend une région double brin formée par le premier et le second brin, et deux extrémités sélectionnées indépendamment du groupe constitué d'une extrémité débordante en 5', d'une extrémité débordante en 3' et d'une extrémité franche. Les molécules d'ARN de la présente invention peuvent être utilisées comme outils de recherche et/ou thérapeutiques.

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