A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4545 (2006.01) A61K 9/19 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/40 (2006.01)
Patent
CA 2512199
The present invention relates to a pharmaceutical composition in aqueous solution form useful for parenteral application to a subject for treatment or prevention of infective disease. In particular the present invention relates to such a composition having as an active agent S-(-)~9-fluoro-6,7-dihydro-8- (4-hydroxypiperidin-l -yl)-5-methyl-l -oxo-1 H,5H-benzo[i,j]quinolizine~2- carboxylic acid, S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-l-yl)-5- methyl-l-oxo~1H,5H-benzo[i,j]quinolizine-2-carboxylic acid 0.2 hydrate or S-(- )-9-fluoro-6,7-dihydro-8-(4~ hydroxypiperidin-l-yl)-5-methyl-l-oxo-1H,5H- benzo[i,j]quinolizine-2-carboxylic acid arginine salt or a benzoquinolizine-2- carboxylic acid antibiotic drug. The field of the invention also includes processes for the preparation of such a composition, the use of such a composition in preparation of a medicament, and to the therapeutic or prophylactic use of such a composition.
L'invention concerne une composition pharmaceutique en solution aqueuse utile pour une application parentérale à un patient destinée au traitement ou à la prévention de maladies infectieuses. Plus précisément, l'invention concerne une composition dont le principe actif est un acide carboxylique de S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypipéridine-l -yl)-5-méthyle-l -oxo-1 H,5H-benzo[i,j]quinolizine-2, un acide carboxylique S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypipéridine-l-yl)-5-méthyle-l-oxo-1H,5H-benzo[i,j]quinolizine-2- 0,2 hydrate ou un sel d'arginine d'acide carboxylique de S-(-)-9-fluoro-6,7-dihydro-8-(4- hydroxypipéridine-l-yl)-5-méthyle-l-oxo-1H,5H-benzo[i,j]quinolizine-2 ou un médicament antibiotique d'acide carboxylique de benzoquinolizine-2. L'invention concerne en outre des procédés de préparation d'une telle composition, son utilisation dans la préparation d'un médicament et son utilisation à des fins thérapeutiques et prophylactiques.
de Souza Noel J.
Nagori Rajendra N.
Saoji Dilip G.
Shetty Nitin
Shukla Milind C.
Smart & Biggar
Wockhardt Limited
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