Compositions of cis-9, trans-11 conjugated linoleic acid and...

A - Human Necessities – 61 – K

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A61K 31/201 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01) A61P 11/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01)

Patent

CA 2629375

The invention relates to use of the cis-9, trans-11 isomer of conjugated linoleic acid or a salt or ester thereof (cis-9, trans-11 CLA) and vaccenic acid or a salt or ester thereof (VA) to treat or prevent conditions associated with one or more of leukocyte infiltration, eosinophilia, airway remodelling, bronchoconstriction, mucus hypersecretion, and lung and skin inflammation. The present invention also relates to a composition comprising cis-9, trans-11 CLA and VA and use of the composition to treat or prevent conditions associated with one or more of leukocyte infiltration, eosinophilia, airway remodelling, bronchoconstriction, mucus hypersecretion, and lung and skin inflammation. In particular, the medicinal uses, compositions and methods of the invention may be used to treat or prevent conditions such as asthma and dermatitis, and related disorders.

La présente invention concerne l'utilisation de l'isomère cis-9, trans-11 d'acide linoléique conjugué ou d'un sel ou ester de celui-ci (cis-9, trans-11 CLA) et d'acide vaccénique ou d'un sel ou ester de celui-ci (VA) pour traiter ou prévenir des pathologies associées à l'un ou plusieurs parmi l'infiltration de leucocytes, l'éosinophilie, le remodelage des voies respiratoires, la bronchoconstriction, l'hypersécrétion de mucus, et l'inflammation des poumons et de la peau. La présente invention concerne en outre une composition comprenant cis-9, trans-11 CLA et VA et l'utilisation de la composition pour traiter ou prévenir des pathologies associées à l'un ou plusieurs parmi l'infiltration de leucocytes, l'éosinophilie, le remodelage des voies respiratoires, la bronchoconstriction, l'hypersécrétion de mucus, et l'inflammation des poumons et de la peau. En particulier, les utilisations médicinales, compositions et procédés de l'invention peuvent être utilisés pour traiter ou prévenir des pathologies telles que l'asthme et la dermatose, et des troubles associés.

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