Compositions of crosslinkable prepolymers for biodegradable...

A - Human Necessities – 61 – L

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A61L 27/16 (2006.01) A61L 27/54 (2006.01) C08F 290/06 (2006.01) C08F 290/14 (2006.01) C08G 63/91 (2006.01)

Patent

CA 2404683

A composition suitable for preparing a biodegradable implant, comprising a crosslinkable multifunctional prepolymer having at least two polymerizable end groups, the said composition having a viscosity such that it is deformable at a temperature of 0° to 60 °C into a three-dimensional shape and being crosslinkable within the said temperature range. The prepolymer comprises a hydrophilic region and/or the composition further comprises an effective amount of a mineral biologically-active component delivery system and/or a biocompatible degradable porosity-inducing component.

L'invention concerne une composition appropriée pour la préparation d'un implant biodégradable, caractérisée en ce qu'elle comprend un prépolymère multifonctionnel réticulable ayant au moins deux groupes terminaux polymérisables, et en ce qu'elle présente une viscosité telle qu'elle est déformable à une température de 0· à 60 ·C en une forme tridimensionnelle, tout en étant réticulable dans ledit intervalle de température. Le prépolymère comprend une région hydrophile et/ou la composition comprend en outre une quantité efficace d'un système produisant un composant minéral biologiquement actif et/ou un composant inducteur de porosité, dégradable de manière biocompatible.

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