A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2601518
The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses.
L'invention concerne des vaccins améliorés comprenant un peptide antigénique viral isolé et un peptide de synthèse obtenu à partir d'un épitope de lymphocyte T de HSP60. L'invention comprend des mélanges dans lesquels le peptide sert d'adjuvant, et des conjugués dans lesquels le peptide est lié de façon covalente à l'antigène viral. Le peptide de synthèse porteur connu, p458, confère une immunogénicité considérablement accrue aux épitopes viraux de synthèse et à leurs analogues. Ec27, qui constitue un nouveau peptide obtenu à partir de HSP60, accroît sensiblement l'immunogénicité de l'antigène viral, dans un mélange ou dans un conjugué covalent. Certains des épitopes viraux isolés sont nouveaux, et sont revendiqués pour des applications diagnostiques, thérapeutiques et prophylactiques.
Cohen Irun R.
Herkel Johannes
Porgador Angel
Rager-Zisman Bracha
B.g. Negev Technologies And Applications Ltd.
Ridout & Maybee Llp
Yeda Research And Development Co. Ltd. At The Weizmann Institute
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