Compositions of iodoaniline derivatives for visualization of...

C - Chemistry – Metallurgy – 07 – C

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C07C 211/52 (2006.01) A61K 49/04 (2006.01) C07C 215/68 (2006.01) C07C 217/76 (2006.01) C07C 219/32 (2006.01) C07C 229/42 (2006.01) C07C 233/15 (2006.01) C07C 255/58 (2006.01)

Patent

CA 2114903

ABSTRACT OF THE DISCLOSURE Disclosed are novel iodoaniline derivatives of the formula: Image (I) (wherein Z is H, halo, C1-C20alkyl, cycloalkyl, lower alkoxy or cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R1 and R2 are independently H, C1-C25alkyl, cycloalkyl, acetyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower- alkoxy carbonyl or lower-alkoxy-carbonyloxy, n is 1-5; y is 1-4; and x is 1 or 2), x-ray contrast compositions containing the iodoaniline derivatives and methods for their use in diagnostic radiology of the gastrointestinal tract.

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