Compositions of iodobenzoic acid derivatives in film-forming...

Details Compositions of iodobenzoic acid derivatives in film-forming... Compositions of iodobenzoic acid derivatives in film-forming...

A - Human Necessities

61

K

A61K 49/04 (2006.01)

Patent

CA 2116831

ABSTRACT Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula Image wherein Z= H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the Alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R= C1-C25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy- carbonyloxy, (CR1R2)p-(CR3=CR4)mQ,or(CR1R2)p-C?C-Q; R1, R2, R3 and R4 are independently lower-alkyl, optionally substituted with halo; x is 1-3 y is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

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