C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 43/18 (2006.01) A61K 49/04 (2006.01) C07C 43/247 (2006.01) C07C 69/712 (2006.01) C07C 69/96 (2006.01) C07C 255/54 (2006.01)
Patent
CA 2105729
Disclosed are contrast agents of the formula Image contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z = H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = C1-C25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy- carbonyloxy, (CR1R2)p - (CR3 = CR4)mQ, or (CRlR2)p - C ? C - Q; R1, R2, R3 and R4 are independently lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
Bacon Edward R.
Caulfield Thomas J.
Cooper Eugene R.
Douty Brent D.
Estep Kimberly G.
Fetherstonhaugh & Co.
Sterling Winthrop Inc.
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