A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/04 (2006.01)
Patent
CA 2105730
ABSTRACT Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula Image and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z = E, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = C1-C25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy- carbonyloxy, (CR1R2)p - (CR3 = CR4)mQ, or (CR1R2)p - C ? C - Q; R1, R2, R3 and R4 are independently lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl in a pharmaceutically acceptable carrier.
Bacon Edward R.
Caulfield Thomas J.
Cooper Eugene R.
Douty Brent D.
Estep Kimberly G.
Fetherstonhaugh & Co.
Sterling Winthrop Inc.
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