Compositions of iodophenyl esters and iodophenyl sulfonates...

A - Human Necessities – 61 – K

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A61K 49/04 (2006.01)

Patent

CA 2115907

ABSTRACT OF THE DISCLOSURE Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula: Image [wherein X is -CO- or -SO2-; Z is H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy or cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R is C1-C25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower- alkoxy, cycloalkyl, hydroxyl, carboxyl, lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy- carbonyloxy, n is 1-5; y is 0-4; and w is 1-4]; and methods for their use in diagnostic radiology of the gastrointestinal tract.

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